Cyclosporin A corrects daunorubicin resistance in Ehrlich ascites carcinoma
نویسندگان
چکیده
منابع مشابه
Enhancement by cyclosporin A of daunorubicin efficacy in Ehrlich ascites carcinoma and murine hepatoma 129.
Cyclosporin A abrogates pleiotropic drug resistance in certain experimental tumors. Its impact on drug-sensitive tumors has not been investigated. Our studies show that in drug-sensitive Ehrlich ascites carcinoma and hepatoma 129 cyclosporin A enhances daunorubicin inhibition of DNA synthesis in vitro and prolongs survival of host mice in vivo. Of particular interest is that cyclosporin A conve...
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Uptake and binding of daunorubicin were studied in a sensitive (EHR 2) and in a resistant (EHR 2/DNR+) subline of Ehrlich ascites tumor cells. At steady state, the celhmedium ratio of daunorubicin was about 10-fold higher in EHR 2 than in EHR 2/DNR + . The bindings of daunorubicin to cell homogenate of the two cell lines were equal when the concentration at equilibrium was below 0.7 fig/ml, whe...
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We have studied the influence of verapamil hydrochloride on the in vitro and in vivo effects of daunorubicin in Ehrlich ascites carcinoma. Daunorubicin-sensitive tumor was rendered resistant to daunorubicin by the continuous treatment of sequential generations of tumor-bearing BALB/c mice. The ability of daunorubicin to inhibit [(3)H]uridine and [(3)H]thymidine incorporation and the effect of d...
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Experimental evidence indicates that Ehrlich ascites tumor cells resistant to daunorubicin (DNR) have a higher active drug extrusion than do wild-type cells. In the present study, the possibility of circumventing this mechanism of resistance by addition of an analog of DNR, N-acetyldaunorubicin (N-acetyl-DNR), was investigated in vitro and in vivo. The affinity of N-acetyl-DNR was 7 times lower...
متن کاملMechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells.
An investigationwas undertakenof the mechanismof a previouslyreportedcross-resistancebetweenvincristine (VCR) and daunorubicin(DNR) in Ehrlichascites tumor cells. No significantdifferencewas demonstratedfor the time course of [3H]VCRuptake in cells resistantto VCR (EHR 2/VCR+) and in cells resistant to DNR (EHR 2/ DNR+), whereaswild-typecellsaccumulatednearly6-fold more drug at steady state. Th...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1986
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1986.167